Injectable Contraceptives for Women at High Risk of Contracting HIV
by Jonathan Abbamonte
Population Research Institute
Since 1991, numerous studies have shown that injectable contraceptives like Depo-Provera may increase women’s risk of contracting HIV. The World Health Organization (WHO) has now changed its recommendations on certain injectable contraceptives in light of mounting evidence and increasing concern.
A new guidance statement recently released by the WHO has moved progestogen-only injectable contraceptives from category 1 to category 2 for women at high risk of contracting HIV.
A meta-analytical study sponsored by the Population Research Institute released last year found that women using certain injectable contraceptives (DMPA-IM) were nearly fifty percent more likely to contract HIV (HR: 1.49, 95% CI 1.28 – 1.73). Other meta-analytical studies using different methods have arrived at similar results.-
Many recent studies have also explored possible biological explanations for why medroxyprogesterone acetate (MPA), the active ingredient in injectable contraceptive like Depo-Provera, may increase the risk for HIV transmission or viral replication.
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